Hepatic Deficiency of Augmenter of Liver Regeneration Predisposes to Nonalcoholic Steatohepatitis and Fibrosis
Abstract
The augmenter of liver regeneration (ALR) protein is critical for lipid homeostasis and mitochondrial function. We investigated high‐fat/high‐carbohydrate (HF/HC) diet–induced nonalcoholic fatty liver disease (NAFLD) in wild‐type (WT), hepatocyte‐specific ALR‐knockout (ALR‐H‐KO), and ALR‐heterozygous (ALR‐H‐HET) mice. ALR was measured in serum of human nonalcoholic steatohepatitis (NASH) and NASH‐induced cirrhosis (serum and liver).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 22, 2020
- Source ID
- 10.1002/hep.31167
Entities
People
- Akanksha Sharma
- Alok K. Verma
- Chandrashekhar R Gandhi
- Jaideep Behari
- Jiang Wang
- Richa Rani
- Rohit Kohli
- Rosa Salazar Gonzalez
- Shimul A. Shah
- Sudhir Kumar
Organizations
- Children's Hospital Los Angeles
- Cincinnati Children's Hospital Medical Center
- Cincinnati VA Medical Center
- University of Cincinnati
- University of Pittsburgh