DNA Methylation Profiling of Human Hepatocarcinogenesis
Abstract
Mutations in TERT (telomerase reverse transcriptase) promoter are established gatekeepers in early hepatocarcinogenesis, but little is known about other molecular alterations driving this process. Epigenetic deregulation is a critical event in early malignancies. Thus, we aimed to (1) analyze DNA methylation changes during the transition from preneoplastic lesions to early HCC (eHCC) and identify candidate epigenetic gatekeepers, and to (2) assess the prognostic potential of methylation changes in cirrhotic tissue.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 15, 2021
- Source ID
- 10.1002/hep.31659
Entities
People
- Amanda J. Craig
- Anna Portela
- Augusto Villanueva
- Bojan Losic
- Edgar Gonzalez‐Kozlova
- Gabriela Hernandez-Meza
- Johann von Felden
- Josep M. Llovet
- Judit Peix
- Manel Esteller
- Myron Schwartz
- Sergi Sayols
- Teresa Garcia‐lezana
- Vincenzo Mazzaferro
Organizations
- Centro de Investigación Biomédica en Red
- Icahn School of Medicine at Mount Sinai
- Institute of Molecular Biology
- National Cancer Institute
- University of Barcelona