DNA Methylation Signatures Reveal the Diversity of Processes Remodeling Hepatocellular Carcinoma Methylomes
Abstract
DNA methylation patterns are highly rearranged in HCCs. However, diverse sources of variation are intermingled in cancer methylomes, precluding the precise characterization of underlying molecular mechanisms. We developed a computational framework (methylation signature analysis with independent component analysis [MethICA]) leveraging independent component analysis to disentangle the diverse processes contributing to DNA methylation changes in tumors.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 01, 2021
- Source ID
- 10.1002/hep.31796
Entities
People
- Amélie Roehrig
- Eric Letouzé
- Gabrielle Couchy
- Jean‐charles Nault
- Jean‐frédéric Blanc
- Jessica Zucman-Rossi
- Josep M. Llovet
- Julien Calderaro
- Léa Meunier
- Quentin Bayard
- Sandrine Imbeaud
- Stefano Caruso
- Théo Z. Hirsch
Organizations
- Catalan Institution for Research and Advanced Studies
- Centre Hospitalier Universitaire de Bordeaux
- Icahn School of Medicine at Mount Sinai
- Sorbonne Paris North University
- Sorbonne University
- University of Barcelona
- University of Bordeaux
- University of Paris-Est