Immune Activation Induces Telomeric DNA Damage and Promotes Short‐Lived Effector T Cell Differentiation in Chronic HCV Infection
Abstract
Hepatitis C virus (HCV) leads to a high rate of chronic infection and T cell dysfunction. Although it is well known that chronic antigenic stimulation is a driving force for impaired T cell functions, the precise mechanisms underlying immune activation–induced T cell dysfunctions during HCV infection remain elusive.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 25, 2021
- Source ID
- 10.1002/hep.32008
Entities
People
- Bal Krishna Chand Thakuri
- Dechao Cao
- Jinyu Zhang
- Jonathan P. Moorman
- Juan Zhao
- Lam Ngoc Thao Nguyen
- Lam Nhat Nguyen
- Ling Wang
- Madison Schank
- Mohamed El Gazzar
- Shunbin Ning
- Sushant Khanal
- Xiao Y. Wu
- Xindi Dang
- Zeyuan Lu
- Zhi Q Yao
Organizations
- East Tennessee State University
- Mountain Home VA Medical Center