Consortium analysis of 7 candidate SNPs for ovarian cancer
Abstract
The Ovarian Cancer Association Consortium selected 7 candidate single nucleotide polymorphisms (SNPs), for which there is evidence from previous studies of an association with variation in ovarian cancer or breast cancer risks. The SNPs selected for analysis were F31I (rs2273535) in AURKA, N372H (rs144848) in BRCA2, rs2854344 in intron 17 of RB1, rs2811712 5′ flanking CDKN2A, rs523349 in the 3′ UTR of SRD5A2, D302H (rs1045485) in CASP8 and L10P (rs1982073) in TGFB1. Fourteen studies genotyped 4,624 invasive epithelial ovarian cancer cases and 8,113 controls of white non‐Hispanic origin. A marginally significant association was found for RB1 when all studies were included [ordinal odds ratio (OR) 0.88 (95% confidence interval (CI) 0.79–1.00) p = 0.041 and dominant OR 0.87 (95% CI 0.76–0.98) p = 0.025]; when the studies that originally suggested an association were excluded, the result was suggestive although no longer statistically significant (ordinal OR 0.92, 95% CI 0.79–1.06). This SNP has also been shown to have an association with decreased risk in breast cancer. There was a suggestion of an association for AURKA, when one study that caused significant study heterogeneity was excluded [ordinal OR 1.10 (95% CI 1.01–1.20) p = 0.027; dominant OR 1.12 (95% CI 1.01–1.24) p = 0.03]. The other 5 SNPs in BRCA2, CDKN2A, SRD5A2, CASP8 and TGFB1 showed no association with ovarian cancer risk; given the large sample size, these results can also be considered to be informative. These null results for SNPs identified from relatively large initial studies shows the importance of replicating associations by a consortium approach. © 2008 Wiley‐Liss, Inc.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 22, 2008
- Source ID
- 10.1002/ijc.23448
Entities
People
- Aleksandra Gentry‐maharaj
- Alice S. Whittemore
- Andrew Berchuck
- Anna H. Wu
- Celeste Leigh Pearce
- Claus Hogdall
- Daniel W. Cramer
- David J. Van Den Berg
- Douglas F. Easton
- Ellen L Goode
- Estrid Høgdall
- Galina Lurie
- Georgia Chenevix‐trench
- Honglin Song
- Jan Blaakaer
- Jenny Chang‐claude
- Joellen M. Schildkraut
- Jolanta Lissowska
- Jonathan Beesley
- Julie M. Cunningham
- Kathryn L. Terry
- Kirsten B. Moysich
- Louise A. Brinton
- Malcolm C Pike
- Marc T. Goodman
- Mark Liebow
- Michael E. Carney
- Montserrat García‐closas
- Patricia G. Moorman
- Paul D.p. Pharoah
- Penelope M. Webb
- Richard A. Dicioccio
- Robert P. Edwards
- Robert Vierkant
- Roberta B. Ness
- Shan Wang‐gohrke
- Sharon E Johnatty
- Shelley S. Tworoger
- Silke Kropp
- Simon A Gayther
- Stephen Chanock
- Susan E. Hankinson
- Susan J. Ramus
- Susanne Krüger Kjaer
- Usha Menon
- Valerie Mcguire
- Xiaoqing Chen
Organizations
- California Breast Cancer Research Program
- California Department of Health Care Services
- Cancer Council Tasmania
- Department of Defence
- Federal Ministry of Research, Technology and Space
- Higher Education Funding Council for England
- Mayo Foundation for Medical Education and Research
- Minnesota Ovarian Cancer Alliance
- National Cancer Institute
- National Health and Medical Research Council
- National Institutes of Health
- Oak Foundation
- United States Army Medical Research and Development Command
- United States Department of Defense
- United States Department of Health and Human Services
- United States Public Health Service