Granulocyte colony‐stimulating factor off‐target effect on nerve outgrowth promotes prostate cancer development
Abstract
The hematopoietic growth factor granulocyte colony‐stimulating factor (G‐CSF) has a role in proliferation, differentiation and migration of the myeloid lineage and in mobilizing hematopoietic stem and progenitor cells into the bloodstream. However, G‐CSF has been newly characterized as a neurotrophic factor in the brain. We recently uncovered that autonomic nerve development in the tumor microenvironment participates actively in prostate tumorigenesis and metastasis. Here, we found that G‐CSF constrains cancer to grow and progress by, respectively, supporting the survival of sympathetic nerve fibers in 6‐hydroxydopamine‐sympathectomized mice and also, promoting the aberrant outgrowth of parasympathetic nerves in transgenic or xenogeneic prostate tumor models. This provides insight into how neurotrophic growth factors may control tumor neurogenesis and may lead to new antineurogenic therapies for prostate cancer.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 09, 2014
- Source ID
- 10.1002/ijc.29046
Entities
People
- Claire Magnon
- Kostantin Dobrenis
- Laurent R. Gauthier
- Vilma Barroca
Organizations
- Albert Einstein College of Medicine
- National Institutes of Health
- United States Department of Defense