Screening for familial and hereditary prostate cancer
Abstract
Prostate cancer (PC) has the highest degree of genetic transmission of any form of malignancy. In some families, the hereditary pattern is so strong as to mimic an autosomal dominance trait. We reviewed the known predisposing genetic markers to assess possible strategies for screening of families at risk. We carried out a systematic literature search using the Pubmed service of the National Center for Biotechnology Information (NCBI) and several gene libraries, including the NCBI SNP Library, the Online Mendelian Inheritance in Man® Catalog of Human Genes and Genetic Disorders (OMIM) and SNPedia to obtain known gene loci, SNPs and satellite markers associated with PC. We further cross referenced information on identified loci comparing data from different articles and gene reference sites. Whenever possible, we recorded the odds ratio (OR) for the allele associated with PC.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 05, 2016
- Source ID
- 10.1002/ijc.29949
Entities
People
- Anthony V. D'amico
- Carrie Snyder
- Henry T. Lynch
- Isaac Powell
- Judd W. Moul
- Marc Rendell
- Omofolasade Kosoko‐lasaki
- Sarah Buxbaum
- Stacy Loeb
- Stephen W. Leslie
- Trudy Shaw
- William B Isaacs
Organizations
- Congressionally Directed Medical Research Programs
- Creighton University
- Harvard Medical School
- Jackson State University
- Johns Hopkins University
- National Institute on Minority Health and Health Disparities
- New York University
- Wayne State University