Follicular pathway role in chemical warfare simulants percutaneous penetration
Abstract
Chemical warfare (CW) exposure could be fatal to military and civilians through skin contamination. Our work and others focus on investigating stratum corneum reservoir with less regards to skin appendageal routes including hair follicles. Here, C‐14 CW simulants (CWS) with specific activity of 0.1 mCi/ml were tested on abdominal and scalp human cadaver skin using flow‐through diffusion system. Quantitative analysis of simulants in skin compartments were performed using scintillation counter. Scalp permeation of dipropylene glycol monomethyl ether (DPGME), diisopropyl methylphosphonate (DIMP) and methyl salicylate (MeS) exceed abdominal skin by 8%, 15%, and 6% (p value p value >0.05). The percentage of applied dose of MeS in scalp showed higher partitioning in stratum corneum and viable epidermis than abdominal skin (p value <0.05).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 08, 2020
- Source ID
- 10.1002/jat.4081
Entities
People
- Akram Elmahdy
- Howard Maibach
- Xiaoying Hui
- Yachao Cao
Organizations
- Defense Threat Reduction Agency
- University of California, San Francisco