Reconnectable fiberscopes for chronic in vivo deep‐brain imaging

Abstract

Reconnectable bundles consisting of thousands of optical fibers are shown to enable high‐quality image transmission, offering a platform for the creation of implantable fiberscopes for minimally invasive in vivo brain imaging. Experiments on various lines of transgenic mice verify the performance of this fiberscope as a powerful tool for chronic in vivo neuroimaging using genetically encoded calcium indicators, neuronal activity markers as well as axon growth regulators and brain‐specific protein drivers in deep regions of live brain.

Document Details

Document Type
Pub Defense Publication
Publication Date
Feb 07, 2018
Source ID
10.1002/jbio.201700106

Entities

People

  • A. B. Fedotov
  • A. M. Zheltikov
  • D. A. Sidorov‐biryukov
  • D.v. Meshchankin
  • I. V. Fedotov
  • K. V. Anokhin
  • M. A. Roshchina
  • M. S. Pochechuev
  • O. I. Ivashkina

Organizations

  • Kazan State Technical University named after A. N. Tupolev
  • Moscow State University
  • National Research Centre Kurchatov Institute
  • Office of Naval Research Global
  • Russian Center for Science Information
  • Russian Quantum Center
  • Russian Science Foundation

Tags

Readers

  • Neuroscience
  • Optical Fiber Sensing and Electromagnetic Propagation.
  • Systems Analysis and Design

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech