Assessing the effect of prolonged use of desloratadine on adipose Brillouin shift and composition in rats
Abstract
Antihistamines, which are commonly used to treat allergic reactions, are known for their side effects, which contribute to weight gain. It is hypothesized that simultaneous Brillouin elastography and Raman spectroscopy can be used to detect changes in adipose tissue associated with a prolonged intake of desloratadine, a commonly used second generation antihistamine. White and brown adipose tissue samples were excised from adult rats following 16 weeks of daily administration of desloratadine. It was found that the prolonged intake of desloratadine leads to an increase in Brillouin shift in both adipose tissue types. Raman spectra indicate that antihistamine use reduces protein‐to‐lipid ratio in brown adipose tissue but not white adipose tissue, indicating the effect on adipose tissue is location‐dependent.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 24, 2020
- Source ID
- 10.1002/jbio.202000269
Entities
People
- Anatoliy Gashev
- Cassidy Gobbell
- Maria Troyanova‐wood
- Olga Gasheva
- Vladislav V Yakovlev
- Zhaokai Meng
Organizations
- Air Force Office of Scientific Research
- Cancer Prevention and Research Institute of Texas
- National Institutes of Health
- National Science Foundation
- United States Army Research Laboratory