Biodegradable polyanhydride‐based nanomedicines for blood to brain drug delivery
Abstract
An urgent need to deliver therapeutics across the blood–brain barrier (BBB) underlies a paucity of effective therapies currently available for treatment of degenerative, infectious, traumatic, chemical, and metabolic disorders of the nervous system. With an eye toward achieving this goal, an in vitro BBB model was employed to simulate biodegradable polyanhydride nanoparticle‐based drug delivery to the brain. Using a combination of confocal microscopy, flow cytometry, and high performance liquid chromatography, we examined the potential of polyanhydride nanoparticles containing the anti‐oxidant, mito‐apocynin, to be internalized and then transferred from monocytes to human brain microvascular endothelial cells. The efficacy of this nanoparticle‐based delivery platform was demonstrated by neuronal protection against oxidative stress. Taken together, this polyanhydride nanoparticle‐based delivery system holds promise for enhancing neuroprotection by facilitating drug transport across the BBB. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2881–2890, 2018.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 26, 2018
- Source ID
- 10.1002/jbm.a.36477
Entities
People
- Anumantha G Kanthasamy
- Balaji Narasimhan
- Balaraman Kalyanaraman
- Benjamin W Schlichtmann
- Biju Bhargavan
- Georgette D. Kanmogne
- Howard E. Gendelman
- Joellyn M. Mcmillan
- Julia E. Vela Ramirez
- Matthew G. Panthani
- Rainie D Nelson
- Surya Mallapragada
- Timothy M. Brenza
- Vellareddy Anantharam
Organizations
- Iowa State University
- Medical College of Wisconsin
- National Science Foundation
- United States Army Medical Research and Development Command
- University of Nebraska–Lincoln