Growth hormone secretagogue receptor‐1a mediates ghrelin's effects on attenuating tumour‐induced loss of muscle strength but not muscle mass
Abstract
Ghrelin may ameliorate cancer cachexia (CC) by preventing anorexia, muscle, and fat loss. However, the mechanisms mediating these effects are not fully understood. This study characterizes the pathways involved in muscle mass and strength loss in the Lewis lung carcinoma (LLC)‐induced cachexia model, and the effects of ghrelin in mice with or without its only known receptor: the growth hormone secretagogue receptor‐1a ((GHSR‐1a), Ghsr+/+ and Ghsr−/−).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 15, 2021
- Source ID
- 10.1002/jcsm.12743
Entities
People
- Alison Tewnion
- Anthony Christiani
- Barbara Anderson
- Beatrice A. Breckheimer
- Brynn Irwin
- Haiming M Liu
- Ian (in‐gi) Lee
- José M. Garcia
- Kora Krumm
- Lena Strait‐bodey
- Mackenzie Storie
- Pu Zang
- Theresa Li
Organizations
- Congressionally Directed Medical Research Programs
- National Institutes of Health
- United States Department of Veterans Affairs
- University of Washington