H19X‐encoded miR‐322(424)/miR‐503 regulates muscle mass by targeting translation initiation factors
Abstract
Skeletal muscle atrophy is a debilitating complication of many chronic diseases, disuse conditions, and ageing. Genome‐wide gene expression analyses have identified that elevated levels of microRNAs encoded by the H19X locus are among the most significant changes in skeletal muscles in a wide scope of human cachectic conditions. We have previously reported that the H19X locus is important for the establishment of striated muscle fate during embryogenesis. However, the role of H19X‐encoded microRNAs in regulating skeletal mass in adults is unknown.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 26, 2021
- Source ID
- 10.1002/jcsm.12827
Entities
People
- Alex Desjarlais
- Anam Syed
- Ashok Kumar
- Benjamin Soibam
- Bradley K. Mcconnell
- Fan Wang
- Fang Yu
- Jin Yang
- M. David Stewart
- Raymond Saba
- Robert J. Schwartz
- Rui Liang
- Shreesti Shrestha
- Xiaopeng Shen
- Xin Wang
- Xuan Ji
- Yinghong Ren
- Yoonjung Park
- Yu Liu
- Zhi Tan
Organizations
- American Heart Association
- Congressionally Directed Medical Research Programs
- National Institutes of Health
- Texas Heart Institute
- University of Houston
- University of Texas at Austin
- Xi'an Jiaotong University