Myalgic encephalomyelitis/chronic fatigue syndrome and gulf war illness patients exhibit increased humoral responses to the herpesviruses‐encoded dUTPase: Implications in disease pathophysiology
Abstract
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI) are debilitating diseases with overlapping symptomology and there are currently no validated tests for definitive diagnosis of either syndrome. While there is evidence supporting the premise that some herpesviruses may act as possible triggers of ME/CFS, the involvement of herpesviruses in the pathophysiology of GWI has not been studied in spite of a higher prevalence of ME/CFS in these patients. We have previously demonstrated that the deoxyuridine triphosphate nucleotidohydrolases (dUTPase) encoded by Epstein‐Barr virus (EBV), human herpesvirus‐6 (HHV‐6), and varicella‐zoster virus (VZV) possess novel functions in innate and adaptive immunity. The results of this study demonstrate that a significant percentage of patients with ME/CFS (30.91‐52.7%) and GWI (29.34%) are simultaneously producing antibodies against multiple human herpesviruses‐encoded dUTPases and/or the human dUTPase when compared to controls (17.21%). GWI patients exhibited significantly higher levels of antibodies to the HHV‐6 and human dUTPases than controls (P = 0.0053 and P = 0.0036, respectively), while the ME/CFS cohort had higher anti‐EBV‐dUTPase antibodies than in both GWI patients (P = 0.0008) and controls (P P = 0.0241). These results suggest that screening of patients’ sera for the presence of various combinations of anti‐dUTPase antibodies could be used as potential biomarkers to help identify/distinguish patients with these syndromes and better direct treatment.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 26, 2017
- Source ID
- 10.1002/jmv.24810
Entities
People
- Maria Eugenia Ariza
- Marshall Vance Williams
- Mary Ann Fletcher
- Nancy G. Klimas
- Peter Halpin
- Zachary Barnes
Organizations
- National Institutes of Health
- Nova Southeastern University
- Ohio State University
- United States Department of Defense
- University of Miami