Two novel recombinant human mastadenovirus D genotypes associated with acute respiratory illness
Abstract
Two novel genotypes of species human mastadenovirus D designated 109 and 110 were isolated from three epidemiologically unrelated cases of acute respiratory disease detected in January 2018 by surveillance efforts at the California/Mexico border. Both genotypes represent examples of intertypic recombination. Genotype D109 is most closely related to genotype D56 (97.68% genomic similarity) and features a type D22‐like penton base, a type D19‐like hexon gene, and a type D9‐like fiber [P22/H19/F9]. On the other hand, genotype D110 is most closely related to type D22 (96.94% genomic similarity) and features a type D67‐like penton base, a novel hexon gene, and a type D9‐like fiber [P67/H110/F9]. Importantly, the fibers of both novel genotypes are highly similar to those of genotypes D56 and D59, which have also been isolated from a few cases of respiratory infections. The present report shows data contributing to the understanding of the molecular determinants of the expanded tissue tropism of certain members of species HAdV‐D.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 01, 2023
- Source ID
- 10.1002/jmv.28653
Entities
People
- Adriana E Kajon
- Caroline Balagot
- Christopher A. Myers
- Esmeralda Iniguez‐stevens
- Gabriel González
- Irais Estrada
- Kyle Pineda
- Matthew Hayes
- Melinda Balansay
- Paula Kriner
- Roger Pan
- Ryan Underwood
Organizations
- Centers for Disease Control and Prevention
- Hokkaido University
- Naval Health Research Center
- Xavier University of Louisiana