Peripheral nerve injury and myelination: Potential therapeutic strategies
Abstract
Traumatic peripheral nerve injury represents a major clinical and public health problem that often leads to significant functional impairment and permanent disability. Despite modern diagnostic procedures and advanced microsurgical techniques, functional recovery after peripheral nerve repair is often unsatisfactory. Therefore, there is an unmet need for new therapeutic or adjunctive strategies to promote the functional recovery in nerve injury patients. In contrast to the central nervous system, Schwann cells in the peripheral nervous system play a pivotal role in several aspects of nerve repair such as degeneration, remyelination, and axonal growth. Several non‐surgical approaches, including pharmacological, electrical, cell‐based, and laser therapies, have been employed to promote myelination and enhance functional recovery after peripheral nerve injury. This review will succinctly discuss the potential therapeutic strategies in the context of myelination following peripheral neurotrauma.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 13, 2019
- Source ID
- 10.1002/jnr.24538
Entities
People
- John C Elfar
- Khatuna Gurgenashvili
- M. A. Hassan Talukder
- Mark Noble
- Max Modrak
Organizations
- Penn State Milton S. Hershey Medical Center
- Pennsylvania State University
- United States Department of Defense
- University of Rochester