Tumor microenvironment and progression
Abstract
Tumor blood vessels are heterogeneous, of at least six distinct types, are induced primarily by vascular endothelial growth factor‐A (VEGF‐A), and provide a potentially useful therapeutic target. Breast cancer is characterized by changes in the microenvironment that result in altered tensional homeostasis. Also, breast cancers arise as the result of epigenetic as well as genetic changes. Tumor blood vessel pericytes result, in part, from bone marrow precursor cells, and VEGF is a negative regulator of glioblastoma tumor cell invasion. J. Surg. Oncol. 2011;103:468–474. © 2011 Wiley‐Liss, Inc.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 07, 2011
- Source ID
- 10.1002/jso.21709
Entities
People
- Gabriele Bergers
- Harold F. Dvorak
- Thea D. Tlsty
- Valerie M Weaver
Organizations
- National Cancer Institute
- National Foundation for Cancer Research
- National Institutes of Health
- Susan G. Komen for the Cure
- United States Department of Defense
- United States Public Health Service