Towards a personalized surgical margin for breast conserving surgery—Implications of field cancerization in local recurrence
Abstract
The amount of normal tissue that should be excised during breast conserving surgery is widely debated. Tissue adjacent to breast tumors, although histologically normal, possesses many of the molecular abnormalities found in tumor tissues. Here, we propose that the ideal physical distance for a surgical margin may not be universal. Rather, an adequate surgical margin likely varies from patient to patient, depending on the biology of the tissue that remains after surgery. J. Surg. Oncol. 2017;115:109–115. © 2017 Wiley Periodicals, Inc.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 05, 2017
- Source ID
- 10.1002/jso.24469
Entities
People
- Anna Jones
- John Russell
- Katarina Lebya
- Kristina Trujillo
- Marco Bisoffi
- Nancy Joste
- Radha Swaminathan
- Randi Garcia‐smith
Organizations
- American Cancer Society
- Chapman University
- National Institutes of Health
- United States Department of Defense
- University of New Mexico