NR5A2 discovering compounds that block tumor growth in PDAC
Abstract
Pancreatic cancers depend on driver molecules, oncogene proteins such as RAS. NR5A2 protein is a transcription factor and either activates or inhibits transcription through actions at hundreds of enhancers. It has unusual properties with effects appearing in multiple signaling networks. NR5A2 is a pluripotency reprogramming factor in the class nuclear receptor. Its controlling hormone is PIP3. Experiments suggest NR5A2 activation drives PDAC and inhibitors blunt cancer cell proliferation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 26, 2017
- Source ID
- 10.1002/jso.24639
Entities
People
- Robert Fletterick
Organizations
- National Institutes of Health
- United States Department of Defense
- University of California, San Francisco