Cell Type–Specific Expression Analysis of the Inner Ear: A Technical Report
Abstract
The cellular diversity of the inner ear has presented a technical challenge in obtaining molecular insight into its development and function. The application of technological advancements in cell type–specific expression enable clinicians and researchers to leap forward from classic genetics to obtaining mechanistic understanding of congenital and acquired hearing loss. This understanding is essential for development of therapeutics to prevent and reverse diseases of the inner ear, including hearing loss. The objective of this study is to describe and compare the available tools for cell type–specific analysis of the ear, as a means to support decision making in study design.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 24, 2020
- Source ID
- 10.1002/lary.28765
Entities
People
- Beatrice Milon
- Kathleen Gwilliam
- Kevin Rose
- Maggie S. Matern
- Ronna Hertzano
Organizations
- Hearing Health Foundation
- National Heart, Lung, and Blood Institute
- National Institute on Deafness and Other Communication Disorders
- United States Department of Defense