Intratympanic Lipopolysaccharide Elevates Systemic Fluorescent Gentamicin Uptake in the Cochlea
Abstract
Lipopolysaccharide (LPS), a key component of bacterial endotoxins, activates macrophages and triggers the release of inflammatory cytokines in mammalian tissues. Recent studies have shown that intratympanic injection of LPS simulates acute otitis media (AOM) and results in morphological and functional changes in the inner ear. Here we established an AOM mouse model with LPS to investigate the uptake of ototoxic gentamicin in the inner ear, and elucidated the underlying mechanism by focusing on cochlear inflammation as a result of AOM.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 06, 2021
- Source ID
- 10.1002/lary.29610
Entities
People
- Alisa P. Hetrick
- Hao Wu
- Hongzhe Li
- Jessica G. Gonzalez
- Liana Sargsyan
- Timothy T. K. Jung
- Weiqiang Yang
- Weiwei He
- Yongchuan Chai
Organizations
- Loma Linda University
- Shanghai Jiao Tong University
- United States Department of Defense
- United States Department of Veterans Affairs