Photodynamic therapy using intra‐articular photofrin for murine MRSA arthritis: Biphasic light dose response for neutrophil‐mediated antibacterial effect
Abstract
Bacterial arthritis does not respond well to antibiotics and moreover multidrug resistance is spreading. We previously tested photodynamic therapy (PDT) mediated by systemic Photofrin® in a mouse model of methicillin‐resistant Staphylococcus aureus (MRSA) arthritis, but found that neutrophils were killed by PDT and therefore the infection was potentiated.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 01, 2011
- Source ID
- 10.1002/lsm.21037
Entities
People
- Koichi Nemoto
- Manabu Kinoshita
- Masamitsu Tanaka
- Michael R. Hamblin
- Nariyoshi Shinomiya
- Shuhji Seki
- Yasuo Yoshihara
- Yuji Morimoto
Organizations
- Congressionally Directed Medical Research Programs
- United States Air Force