Identifying the Role of Block Length in Neural Heat Block to Reduce Temperatures During Infrared Neural Inhibition
Abstract
The objective of this study is to assess the hypothesis that the length of axon heated, defined here as block length (BL), affects the temperature required for thermal inhibition of action potential propagation applied using laser heating. The presence of such a phenomenon has implications for how this technique, called infrared neural inhibition (INI), may be applied in a clinically safe manner since it suggests that temperatures required for therapy may be reduced through the proper spatial application of light. Here, we validate the presence of this phenomenon by assessing how the peak temperatures during INI are reduced when two different BLs are applied using irradiation from either one or two adjacent optical fibers.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 25, 2019
- Source ID
- 10.1002/lsm.23139
Entities
People
- E Duco Jansen
- Hillel J Chiel
- Jeremy B Ford
- Megan E Poorman
- Michael W Jenkins
- Mohit Ganguly
- William Grissom
Organizations
- Air Force Office of Scientific Research
- American Society for Laser Medicine and Surgery
- Case Western Reserve University
- Foundation for the National Institutes of Health
- Vanderbilt University