Antimicrobial Blue Light Inactivation of Microbial Isolates in Biofilms
Abstract
Biofilms cause more than 80% of infections in humans, including more than 90% of all chronic wound infections and are extremely resistant to antimicrobials and the immune system. The situation is exacerbated by the fast spreading of antimicrobial resistance, which has become one of the biggest threats to current public health. There is consequently a critical need for the development of alternative therapeutics. Antimicrobial blue light (aBL) is a light‐based approach that exhibits intrinsic antimicrobial effect without the involvement of exogenous photosensitizers. In this study, we investigated the antimicrobial effect of this non‐antibiotic approach against biofilms formed by microbial isolates of multidrug‐resistant bacteria.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 19, 2019
- Source ID
- 10.1002/lsm.23159
Entities
People
- Raquel Ferrer-Espada
- Tianhong Dai
- Xueping Sharon Goh
- Ying Wang
Organizations
- Harvard Medical School
- National Institutes of Health
- United States Department of Defense