Bacterial Nanocellulose Magnetically Functionalized for Neuro‐Endovascular Treatment
Abstract
Current treatments for brain aneurysms are invasive, traumatic, and not suitable in most patients with increased risks. A new alternative method is using scaffold stents to create a local and focal attraction force of cells for an in situ reconstruction of the tunica media. For this purpose, a nanostructured bioactive coating is designed to render an asymmetric region of the stent scaffold magnetic and biomimetic, which utilizes bacterial nanocellulose (BNC) as a platform for both magnetic and cell attraction as well as proliferation. The magnetization of the BNC is realized through the reaction of Fe III and II, precipitating superparamagnetic iron oxide nanoparticles (SPION). Subsequently, magnetic bacterial nanocellulose (MBNC) is coated with polyethylene glycol to improve its biocompatibility. Cytotoxicity and biocompatibility are evaluated using porcine aortic smooth muscle cells. Preliminary cellular migration assays demonstrate the behavior between MBNC and cells labeled with SPION. In this work, (1) synthesis of BNC impregnated with magnetic nanoparticles is successfully demonstrated; (2) a viable, resilient, and biocompatible hydrogel membrane is tested for neuroendovascular application using a stent scaffold; (3) cell viability and minimal cytotoxicity is achieved; (4) cell migration tests and examination of cellular magnetic attraction confirm the viability of MBNC as a multifunctional coating. image
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 24, 2017
- Source ID
- 10.1002/mabi.201600382
Entities
People
- Akshath R. Shetty
- Fernando Pastrana
- Jean Paul Allain
- Juan Jose Pavón
- Lisa M. Reece
- Mónica Echeverry‐rendon
- Sandra L. Arias
Organizations
- Purdue University
- United States Department of Defense
- University of Antioquia
- University of Illinois Urbana–Champaign
- University of Texas Medical Branch
- University of the Andes