Anion‐Mediated Effects on the Size and Mechanical Properties of Enzymatically Crosslinked Suckerin Hydrogels
Abstract
The suckerin family of proteins, identified from the squid sucker ring teeth assembly, offers unique mechanical properties and potential advantages over other natural biomaterials. In this study, a small suckerin isoform, suckerin‐12, is used to create enzymatically crosslinked, macro‐scale hydrogels. Upon exposure to specific salt conditions, suckerin‐12 hydrogels contracted into a condensed state where mechanical properties are found to be modulated by the salt anion present. The rate of contraction is found to correlate well with the kosmotropic arm of the Hofmeister anion series. However, the observed changes in hydrogel mechanical properties are better explained by the ability of the salt to neutralize charges in suckerin‐12 by deprotonization or charge screening. Thus, by altering the anions in the condensing salt solution, it is possible to tune the mechanical properties of suckerin‐12 hydrogels. The potential for suckerins to add new properties to materials based on naturally‐derived proteins is highlighted.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 08, 2018
- Source ID
- 10.1002/mabi.201800238
Entities
People
- Chelsea C. Buck
- Joseph M. Slocik
- Kellie A. Becknell
- Kristen K Comfort
- Maneesh K Gupta
- Marcus T. Grant
- Marquise G Crosby
- Patrick B Dennis
- Peter A Mirau
- Rajesh R Naik
Organizations
- Air Force Office of Scientific Research
- Air Force Research Laboratory
- Office of the Secretary of Defense
- University of Dayton