Enzyme‐Responsive Polymer Nanoparticles via Ring‐Opening Metathesis Polymerization‐Induced Self‐Assembly
Abstract
Open‐to‐air aqueous‐phase ring‐opening metathesis polymerization‐induced self‐assembly (ROMPISA) is reported for forming well‐defined peptide polymer nanoparticles at room temperature and with high solids concentrations (10 w/w%). For these materials, ROMPISA is shown to provide control over molecular weight with high conversion while open‐to‐air. Moreover, these peptide polymer nanoparticles can spontaneously rearrange into larger aggregate scaffolds in the presence of the proteolytic enzyme, thermolysin. This work demonstrates the robust nature of ROMPISA, highlighted here for the preparation of stimuli‐responsive nanostructures in one pot, in air.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 03, 2018
- Source ID
- 10.1002/marc.201800467
Entities
People
- Andrea S. Carlini
- Daniel B. Wright
- Matthew P. Thompson
- Mollie A. Touve
- Nathan C. Gianneschi
Organizations
- Air Force Office of Scientific Research
- Northwestern University
- Yusuf Hamied Department of Chemistry