Coordination Stoichiometry Effects on the Binding Hierarchy of Histamine and Imidazole–M2+Complexes
Abstract
Histidine–M2+coordination bonds are a recognized bond motif in biogenic materials with high hardness and extensibility, which has led to growing interest in their use in soft materials for mechanical function. However, the effect of different metal ions on the stability of the coordination complex remains poorly understood, complicating their implementation in metal‐coordinated polymer materials. Herein, rheology experiments and density functional theory calculations are used to characterize the stability of coordination complexes and establish the binding hierarchy of histamine and imidazole with Ni2+, Cu2+, and Zn2+. It is found that the binding hierarchy is driven by the specific affinity of the metal ions to different coordination states, which can be macroscopically tuned by changing the metal‐to‐ligand stoichiometry of the metal‐coordinated network. These findings facilitate the rational selection of metal ions for optimizing the mechanical properties of metal‐coordinated materials.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 05, 2023
- Source ID
- 10.1002/marc.202300077
Entities
People
- Eesha Khare
- Jake Song
- Li Rao
- Markus J. Buehler
- Niels Holten-Andersen
Organizations
- Army Research Office
- Central China Normal University
- Lehigh University
- Massachusetts Institute of Technology