Multiple system atrophy and apolipoprotein E
Abstract
Background: Dysregulation of the specialized lipid metabolism involved in myelin synthesis and maintenance by oligodendrocytes has been associated with the unique neuropathology of MSA. We hypothesized that apolipoprotein E, which is associated with neurodegeneration, may also play a role in the pathogenesis of MSA.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 14, 2018
- Source ID
- 10.1002/mds.27297
Entities
People
- Alexandra I. Soto
- Anna I. Wernick
- Catherine Labbé
- Dennis W. Dickson
- Emily R. Vargas
- Guojun Bu
- Henrietta M. Nielsen
- Jay A. Van Gerpen
- Kotaro Ogaki
- Michael G. Heckman
- Oswaldo Lorenzo‐betancor
- Owen A. Ross
- Phillip A. Low
- Ronald L. Walton
- Ryan J. Uitti
- Shinsuke Fujioka
- Shunsuke Koga
- Takahisa Kanekiyo
- William P. Cheshire
- Wolfgang Singer
- Yuka A. Martens
- Zbigniew K Wszolek
Organizations
- Alzheimer's Association
- Boston Scientific
- Cure Alzheimer's Fund
- Mayo Clinic
- Mayo Clinic Graduate School of Biomedical Sciences
- National Institute of Neurological Disorders and Stroke
- Stockholm University
- The Michael J. Fox Foundation
- United States Department of Defense