Global and Regional Changes in Perivascular Space in Idiopathic and Familial Parkinson's Disease
Abstract
The glymphatic system, including the perivascular space (PVS), plays a critical role in brain homeostasis. Although mounting evidence from Alzheimer's disease has supported the potential role of PVS in neurodegenerative disorders, its contribution in Parkinson's disease (PD) has not been fully elucidated. Although idiopathic (IPD) and familial PD (FPD) share similar pathophysiology in terms of protein aggregation, the differential impact of PVS on PD subtypes remains unknown. Our objective was to examine the differences in PVS volume fraction in IPD and FPD compared to healthy controls (HCs) and nonmanifest carriers (NMCs).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 20, 2021
- Source ID
- 10.1002/mds.28473
Entities
People
- Amjad Murdos
- Arthur W. Toga
- Erin K. Donahue
- Farshid Sepehrband
- Giselle M. Petzinger
- Michael W. Jakowec
- Nasim Sheikh‐bahaei
Organizations
- Avid Radiopharmaceuticals
- Bristol-Myers Squibb
- GE HealthCare
- National Institutes of Health
- Parkinson's Foundation
- United States Army
- United States Department of Defense
- University of Southern California