Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk

Abstract

The leucine‐rich repeat kinase 2 (LRRK2) gene harbors both rare highly damaging missense variants (eg, p.G2019S) and common noncoding variants (eg, rs76904798) with lower effect sizes that are associated with Parkinson's disease (PD) risk.

Document Details

• Document Type: Pub Defense Publication
• Publication Date: Sep 20, 2021
• Source ID: 10.1002/mds.28787

Entities

People

• Andrew B. Singleton
• Cornelis Blauwendraat
• Hampton Leonard
• Julie Lake
• Mark R Cookson
• Mike A. Nalls
• Rebekah G. Langston
• The International Parkinson's Disease Genomics Consortium (ipdgc)
• Xylena Reed
• Ziv Gan-Or

Organizations

• Fondation de France
• German Center for Neurodegenerative Diseases
• McGill University
• Medical Research Council Canada
• National Institute of Environmental Health Sciences
• National Institute of Neurological Disorders and Stroke
• National Institute on Aging
• National Institutes of Health
• Parkinson's UK
• United States Department of Defense
• Wellcome

Tags

Readers

• Missile Defense Systems.
• Molecular and genetic basis of cancer.
• Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.