Alpha‐Synuclein is Involved in DYT1 Dystonia Striatal Synaptic Dysfunction
Abstract
The neuronal protein alpha‐synuclein (α‐Syn) is crucially involved in Parkinson's disease pathophysiology. Intriguingly, torsinA (TA), the protein causative of DYT1 dystonia, has been found to accumulate in Lewy bodies and to interact with α‐Syn. Both proteins act as molecular chaperones and control synaptic machinery. Despite such evidence, the role of α‐Syn in dystonia has never been investigated.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 14, 2022
- Source ID
- 10.1002/mds.29024
Entities
People
- Annalisa Tassone
- Antonio Pisani
- Arianna Bellucci
- Gaia Faustini
- Giulia Ponterio
- Giuseppe Sciamanna
- Giuseppina Martella
- Ilham El Atiallah
- Maria Meringolo
- Paola Bonsi
- Paola Imbriani
- Silvia Cerri
Organizations
- Horizon 2020
- Ministry of Health of Italy
- Sapienza University of Rome
- United States Department of Defense
- University of Brescia
- University of Pavia