Pathway‐Specific Remodeling of Thalamostriatal Synapses in a Mouse Model of Parkinson's Disease
Abstract
The network pathophysiology underlying the motor symptoms of Parkinson's disease (PD) is poorly understood. In models of late‐stage PD, there is significant cell‐specific remodeling of corticostriatal, axospinous glutamatergic synapses on principal spiny projection neurons (SPNs). Neurons in the centrolateral nucleus (CLN) of the thalamus that relay cerebellar activity to the striatum also make axospinous synapses on SPNs, but the extent to which they are affected in PD has not been definitively characterized.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 29, 2022
- Source ID
- 10.1002/mds.29030
Entities
People
- Asami Tanimura
- D. James Surmeier
- David Wokosin
- Weixing Shen
Organizations
- Aarhus University
- CHDI Foundation
- Freedom Together Foundation
- National Institutes of Health
- Northwestern University
- The Michael J. Fox Foundation
- United States Department of Defense