Nicotine‐Mediated Rescue of α‐Synuclein Toxicity Requires Synaptic Vesicle Glycoprotein 2 in Drosophila

Abstract

Parkinson's disease (PD) is characterized by α‐synuclein aggregation and loss of dopamine neurons. Risk of PD arises due to a combination of genetic and environmental factors, which may interact, termed gene–environment (G×E) interactions. An inverse association between smoking and the risk of PD is well established, and a previous genome‐wide G×E interaction study identified genetic variation in the synaptic‐vesicle glycoprotein 2C (SV2C) locus as an important mediator of the degree to which smoking is inversely associated with PD.

Document Details

• Document Type: Pub Defense Publication
• Publication Date: Nov 23, 2022
• Source ID: 10.1002/mds.29283

Entities

People

• Abby Olsen
• Mel B. Feany
• Sabrina G. Clemens

Organizations

• Aligning Science Across Parkinson's
• Brigham and Women's Hospital
• National Institute of Neurological Disorders and Stroke
• The Michael J. Fox Foundation
• United States Department of Defense

Tags

Fields of Study

• Biology

Readers

• Molecular Biology and Genetics
• Molecular and genetic basis of cancer.
• Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.

Technology Areas

• Biotechnology