Controlling axonal regeneration with acellular nerve allograft limits neuroma formation in peripheral nerve transection: An experimental study in a swine model
Abstract
Symptomatic neuromata are a common indication for revision surgery following amputation. Previously described treatments, including traction neurectomy, nerve transposition, targeted muscle re‐innervation, and nerve capping, have provided inconsistent results or are technically challenging. Prior research using acellular nerve allografts (ANA) has shown controlled termination of axonal regrowth in long grafts. The purpose of this study was to determine the ability of a long ANA to prevent neuroma formation following transection of a peripheral nerve in a swine model.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 04, 2022
- Source ID
- 10.1002/micr.30943
Entities
People
- Allison Tomasino
- Amy M Moore
- Benjamin Wheatley
- Crystal Leonhardt
- Daniel A. Hunter
- Matthew D. Wood
- Patrick D. Grimm
- Scott M. Tintle
- Thomas A. Davis
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- Naval Medical Research Center
- Ohio State University
- Uniformed Services University of the Health Sciences
- United States Department of Defense
- Washington University in St. Louis