Amide proton transfer CEST of the cervical spinal cord in multiple sclerosis patients at 3T
Abstract
The ability to evaluate pathological changes in the spinal cord in multiple sclerosis (MS) is limited because T1‐ and T2‐w MRI imaging are not sensitive to biochemical changes in vivo. Amide proton transfer (APT) chemical exchange saturation transfer (CEST) can indirectly detect amide protons associated with proteins and peptides, potentially providing more pathological specificity. Here, we implement APT CEST in the cervical spinal cord of healthy and MS cohorts at 3T.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 05, 2017
- Source ID
- 10.1002/mrm.26736
Entities
People
- Alex K Smith
- Bailey A. Box
- Bailey D. Lyttle
- Francesca R. Bagnato
- Robert L Barry
- Samantha By
- Seth A. Smith
- Siddharama Pawate
Organizations
- Harvard Medical School
- Massachusetts General Hospital
- National Eye Institute
- National Institute of Biomedical Imaging and Bioengineering
- National Institute of Neurological Disorders and Stroke
- National Multiple Sclerosis Society
- United States Department of Defense
- University of Oxford
- Vanderbilt University