Fast whole brain MR imaging of dynamic susceptibility contrast changes in the cerebrospinal fluid (cDSC MRI)
Abstract
The circulation of cerebrospinal fluid (CSF) is closely associated with many aspects of brain physiology. When gadolinium(Gd)‐based contrast is administered intravenously, pre‐ and post‐contrast MR signal changes can often be observed in the CSF at certain locations within the intra‐cranial space, mainly due to the lack of a blood‐brain barrier in the dural blood vessels. This study aims to develop and systemically optimize MRI sequences that can detect dynamic signal changes in the CSF after Gd administration with a sub‐millimeter spatial resolution, a temporal resolution of <10 s, and whole brain coverage.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 03, 2020
- Source ID
- 10.1002/mrm.28389
Entities
People
- Adrian Paez
- Di Cao
- Jay J. Pillai
- Jiadi Xu
- Jun Hua
- Ningdong Kang
- Peter Barker
- Peter C. M. Van Zijl
- Qin Qin
- Xiang Xu
- Xinyuan Miao
- Xu Li
Organizations
- Johns Hopkins University
- Kennedy Krieger Institute
- National Institutes of Health
- United States Department of Defense