Effect Of combining FK506 and neurotrophins on neurite branching and elongation
Abstract
There is a clinical need to improve the outcomes of peripheral nerve regeneration and repair after injury. In addition to its immunosuppressive effects, FK506 (tacrolimus) has been shown to have neuroregenerative properties. To determine biologically relevant local FK506 and growth factor concentrations, we performed an in vitro bioassay using dorsal root ganglion (DRG) from chicken embryos.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 28, 2016
- Source ID
- 10.1002/mus.25370
Entities
People
- Bruce K. Gale
- Himanshu Sant
- Jayant Agarwal
- Jill Shea
- Pratima Labroo
Organizations
- United States Department of Defense
- University of Utah