4‐Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice
Abstract
We recently demonstrated the beneficial effects of 4‐aminopyridine (4‐AP), a potassium channel blocker, in enhancing remyelination and recovery of nerve conduction velocity and motor function after sciatic nerve crush injury in mice. Although muscle atrophy occurs very rapidly after nerve injury, the effect of 4‐AP on muscle atrophy and intrinsic muscle contractile function is largely unknown.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 30, 2019
- Source ID
- 10.1002/mus.26516
Entities
People
- Anagha Gurjar
- Joe V. Chakkalakal
- John C Elfar
- Jung Il Lee
- M. A. Talukder
- Mark Noble
- Robert T. Dirksen
- Yue Li
Organizations
- Brown University
- Hanyang University
- Pennsylvania State University
- United States Department of Defense
- University of Rochester