Voluntary exercise improves voiding function and bladder hyperalgesia in an animal model of stress‐induced visceral hypersensitivity: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome research network study
Abstract
The underlying mechanism of interstitial cystitis/bladder pain syndrome (IC/BPS) is not well understood and evaluation of current therapeutic interventions has not identified any generally effective treatments. Physical activity has shown beneficial effects on individuals suffering from chronic pain. Anxiety‐prone rats exposed to water avoidance stress (WAS) develop urinary frequency and lower bladder sensory thresholds with high face and construct validity for the study of IC/BPS. The aim of this study was to evaluate the role of chronic voluntary exercise on urinary frequency, voiding function, and hyperalgesia in animals exposed to WAS.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 13, 2020
- Source ID
- 10.1002/nau.24270
Entities
People
- Daniel P Holschneider
- Jackie J. Mao
- Jih‐chao Yeh
- Larissa V. Rodriguez
- Melissa T Sanford
- Rong Zhang
- Yumei Guo
- Zhuo Wang
Organizations
- National Institute of Diabetes and Digestive and Kidney Diseases
- Texas Tech University
- United States Department of Defense
- University of Southern California