Dynamic oxygen challenge evaluated by NMR T1 and T2* – insights into tumor oxygenation
Abstract
There is intense interest in developing non‐invasive prognostic biomarkers of tumor response to therapy, particularly with regard to hypoxia. It has been suggested that oxygen sensitive MRI, notably blood oxygen level‐dependent (BOLD) and tissue oxygen level‐dependent (TOLD) contrast, may provide relevant measurements. This study examined the feasibility of interleaved T2*‐ and T1‐weighted oxygen sensitive MRI, as well as R2* and R1 maps, of rat tumors to assess the relative sensitivity to changes in oxygenation. Investigations used cohorts of Dunning prostate R3327‐AT1 and R3327‐HI tumors, which are reported to exhibit distinct size‐dependent levels of hypoxia and response to hyperoxic gas breathing. Proton MRI R1 and R2* maps were obtained for tumors of anesthetized rats (isoflurane/air) at 4.7 T. Then, interleaved gradient echo T2*‐ and T1‐weighted images were acquired during air breathing and a 10 min challenge with carbogen (95% O2–5% CO2).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 08, 2015
- Source ID
- 10.1002/nbm.3325
Entities
People
- Dawen Zhao
- Derek White
- Jesús Pacheco‐torres
- Peter Peschke
- Ralph P. Mason
- Rami R. Hallac
- Sebastian Cerdán
Organizations
- German Cancer Research Center
- National Institutes of Health
- Spanish National Research Council
- United States Department of Defense
- University of Texas at Austin