Hyperinsulinemia is a probable trigger for weight gain and hyperphagia in individuals with Prader‐Willi syndrome
Abstract
Prader‐Willi syndrome (PWS) is the most frequently diagnosed genetic cause of early childhood obesity. Individuals with PWS typically progress through 7 different nutritional phases during their lifetime. The main objective of this study was to assess potential factors, particularly insulin, that may be responsible for the weight gains in sub‐phase 2a and their role in the subsequent increase in fat mass and obesity in sub‐phase 2b and insatiable appetite in phase 3.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 17, 2023
- Source ID
- 10.1002/osp4.663
Entities
People
- Carlos R. Sulsona
- Daniel J Driscoll
- Frederick A. Kweh
- Jennifer L. Miller
Organizations
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- National Institutes of Health
- United States Department of Defense
- University of Florida