Proteomic analysis of cerebrospinal fluid in California sea lions (Zalophus californianus) with domoic acid toxicosis identifies proteins associated with neurodegeneration
Abstract
Proteomic studies including marine mammals are rare, largely due to the lack of fully sequenced genomes. This has hampered the application of these techniques toward biomarker discovery efforts for monitoring of health and disease in these animals. We conducted a pilot label‐free LC‐MS/MS study to profile and compare the cerebrospinal fluid from California sea lions with domoic acid toxicosis (DAT) and without DAT. Across 11 samples, a total of 206 proteins were identified (FDRhttp://proteomecentral.proteomexchange.org/dataset/PXD002105).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 13, 2015
- Source ID
- 10.1002/pmic.201500167
Entities
People
- Benjamin A. Neely
- Frances M. D. Gulland
- Jennifer L. Soper
- John M. Arthur
- Mark Kindy
- Michael G. Janech
- P. Darwin Bell
Organizations
- Department of Veterans' Affairs
- Medical University of South Carolina
- Office of Naval Research
- The Marine Mammal Center
- University of Arkansas for Medical Sciences