Biodegradable photocrosslinkable poly(depsipeptide‐co‐ε‐caprolactone) for tissue engineering: Synthesis, characterization, and In vitro evaluation
Abstract
Stereolithography has become increasingly popular in scaffold fabrication due to automation and well‐controlled geometry complexity, and consequently, there is a great need for new suitable biodegradable photocrosslinkable polymers. In this study, a new type of photocrosslinkable poly(ester amide) was synthesized based on ε‐caprolactone and l‐alanine‐derived depsipeptide and was applied to fabrication of three‐dimensional (3D) scaffolds by stereolithography. 1H nuclear magnetic resonance and Fourier transform infra‐red analysis confirmed the formation of new bonds during the polymer synthesis. Incorporation of depsipeptide increased the glass transition temperature and hydrophilicity of the polymer and accelerated hydrolytic degradation compared with the poly(ε‐caprolactone) homopolymer. The compressive strength of the 3D scaffolds increased with the increasing depsipeptide content. This work demonstrated that incorporation of depsipeptide into photocrosslinkable polyesters resulted in excellent cytocompatibility and tunable degradation rates and mechanical properties and thus expanded the repertoire of biomaterials suitable for 3D photofabrication of high‐resolution tissue engineering scaffolds. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 3307–3315
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 25, 2014
- Source ID
- 10.1002/pola.27400
Entities
People
- Jukka V. Seppälä
- Laura Elomaa
- Yunqing Kang
- Yunzhi Yang
Organizations
- Aalto University
- National Institutes of Health
- Stanford University
- United States Department of Defense
- Wallace H. Coulter Foundation