Active sonic hedgehog signaling between androgen independent human prostate cancer cells and normal/benign but not cancer‐associated prostate stromal cells
Abstract
Sonic hedgehog (Shh) signaling plays a pivotal role in stromal–epithelial interaction during normal development but its role in tumor–stromal interaction during carcinogenic progression is less well defined. Since hormone refractory prostate cancer with bone metastasis is difficult to treat, it is crucial to investigate how androgen independent (AI) human prostate cancer cells communicate with their associated stroma.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 25, 2011
- Source ID
- 10.1002/pros.21388
Entities
People
- Akinobu Gotoh
- Fray F. Marshall
- Guodong Zhu
- Haiyen E. Zhau
- Jingwu Xie
- Katsumi Shigemura
- Leland W. K. Chung
- Masato Fujisawa
- Wen‐chin Huang
- Xiangyan Li
Organizations
- United States Department of Defense