Androgens repress expression of the f‐box protein Skp2 via p107 dependent and independent mechanisms in LNCaP prostate cancer cells
Abstract
Androgens control homeostasis of the normal prostate and growth of prostate cancer (PCa) through the androgen receptor (AR) by regulating gene networks involving in cell proliferation, differentiation, and survival. We demonstrated previously that expression of Skp2, a key protein regulating cell entry into the S phase, is inhibited by androgens in an AR‐dependent manner (Oncogene, 2004; 23(12): 2161–2176). However, the underlying mechanism of this regulation is unknown.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 31, 2011
- Source ID
- 10.1002/pros.21430
Entities
People
- Changping Wu
- Donald J. Tindall
- Haojie Huang
- Jingting Jiang
- Kevin M. Regan
- Xueguang Zhang
- Yunqian Pan
Organizations
- National Institutes of Health
- United States Department of Defense