T cells localized to the androgen‐deprived prostate are TH1 and TH17 biased
Abstract
T cells infiltrate the prostates of prostate cancer patients undergoing neoadjuvant androgen deprivation. These prostate‐infiltrating T cells have an oligoclonal phenotype, suggesting the development of an antigen‐specific T‐cell response. We hypothesized that androgen deprivation might elicit a prostate tissue‐specific T‐cell response that could potentially be combined with other immune‐active therapies, and consequently sought to investigate the nature and timing of this T‐cell response following castration.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 27, 2011
- Source ID
- 10.1002/pros.22476
Entities
People
- Douglas G. Mcneel
- Matthew D. Morse
Organizations
- National Institutes of Health