The activity of the androgen receptor variant AR‐V7 is regulated by FOXO1 in a PTEN‐PI3K‐AKT‐dependent way
Abstract
The androgen receptor (AR) AR‐V7 splice isoform is a constitutively active outlaw transcription factor. Transition of prostate cancer (PC) to the castration‐resistant phenotype correlates with AR‐V7 accumulation, suggesting that PC progression in patients refractory to conventional therapy is due to the activity of this AR isoform. The mechanism of AR‐V7 constitutive activation is not known.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 20, 2012
- Source ID
- 10.1002/pros.22566
Entities
People
- Adam T. Szafran
- Guru Sonpavde
- Huiying Sun
- Marco Marcelli
- Michael A. Mancini
- Perumal Thiagarajan
- Sanjay N. Mediwala
- Sean M Hartig
- Teresa G. Hayes
Organizations
- Dan L. Duncan Cancer Center, Baylor College of Medicine