Selenoprotein P genetic variants and mrna expression, circulating selenium, and prostate cancer risk and survival
Abstract
Low levels of selenium have been associated with increased risk of prostate cancer (PCa). Selenoprotein P is the most abundant selenoprotein in serum and delivers ten selenocysteine residues to tissues. Variation in the selenoprotein P gene (SEPP1) may influence PCa development or modify the effects of selenium. We examined the association of SEPP1 single nucleotide polymorphisms (SNPs) with PCa risk and survival, and tested for interactions.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 05, 2012
- Source ID
- 10.1002/pros.22611
Entities
People
- Hao Li
- Howard D Sesso
- Jing Ma
- Kathryn L. Penney
- Lorelei A. Mucci
- Massimo Loda
- Meir J. Stampfer
Organizations
- National Cancer Institute
- National Heart, Lung, and Blood Institute
- Prostate Cancer Foundation
- United States Department of Defense