Negative regulation of NEP expression by hypoxia
Abstract
Neutral endopeptidase (NEP) is a transmembrane cell surface peptidase present on prostatic epithelial cells that catalytically inactivates small peptide substrates. Neutral endopeptidase loss is associated with prostate cancer growth, progression, and increased angiogenesis. We examined whether NEP expression is regulated by hypoxia, frequently encountered in the tumor microenvironment.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 08, 2012
- Source ID
- 10.1002/pros.22613
Entities
People
- David M. Nanus
- Olivia S. Chao
- Oscar B. Goodman Jr.
- Ranjana Mitra
Organizations
- United States Department of Defense